"Innate Immunity": HTML5 Crossword

Across

4. A type of “found you” innate defense that are communication proteins that are produced and released by human cells to communicate the presence of microbes and/or foreign molecules in order to produce a response to eliminate the threat. (9)
6. A type of “get rid of you” innate defense that involves a process where certain white blood cells will engulf microbes and other foreign materials and breaking them down. (12)
9. A type of “keep out” defense composed of dead keratinocytes and many layers of waterproofed cells that frequently shed. This is a very effective barrier unless it is injured/broken. (4)
11. A type of “keep out” innate defense composed of a viscous fluid that is produced by specialized cells in the respiratory tract, digestive tract, and urogenital tract to trap and remove microbes and acts as a barrier to the cells below it. (5)
17. A type of “keep out” innate defense that are tiny proteins that are continually made and secreted by human cells that have antimicrobial properties. (13,8)
19. A type of “get rid of you” innate defense that is a process that results in cells killing themselves (e.g. if they are infected or malfunctioning cells). (9)
20. A type of “get rid of you” innate defense that causes the body’s temperature setpoint to increase by stimulating the hypothalamus with cytokines. (5)

Down

1. A type of “keep out” innate defense that is a variety of microbes living inside of humans that will occupy habitat and use up excess nutrients so pathogenic microbes cannot, communicates with the human immune system, and produces compounds that inhibit pathogenic microbes. (10)
2. The “_______” defenses is a category of non-specific defenses that identifies microbes located in the human body and creates an alert signal to initiate a response. (5,3)
3. The “_______” defenses is a category of non-specific defenses that prevent microbes from entering the human body or from establishing infection in the human body. (4,3)
5. _______ immunity involves human immune defenses that protect against any microbe. (6)
7. When immune processes are stuck in a feedback loop where too many signaling molecules are produced signaling a microbe and/or foreign molecules, this possibly deadly situation can result in organ damage and organ failure. (8,5)
8. A type of “get rid of you” innate defense that involves heat, swelling, pain, and redness. (12)
10. A type of “found you” innate defense that involves proteins embedded in the plasma membrane of human cells that are shape-specific proteins that can bind to molecules to detect them it the cell’s environment. (7,9)
12. ________ are one of two different types of phagocytes. This one is NOT often dubbed as a “big-eater cell,” even though it does conduct phagocytosis. (11)
13. ________ are one of two different types of phagocytes. This one is called a “big-eater” cell. (11)
14. The “_______” defenses is a category of non-specific defenses that takes action to eliminate microbes located in the human body. (3,3,2,3)
15. ________ are drugs that might be used to clear up a bacterial infection, but can harm the microbiome. (11)
16. A type of “keep out” innate defense that is an enzyme continually produced and secreted into tears, mucus, blood, and other body fluids that will break down peptidoglycan to defend against bacteria. (8)
18. _______ immunity involves human immune defenses that target specific microbes. (8)